Abcam, ab238168, Anti-FoxJ1 antibody [EPR21874] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FOXJ1 antibody. Carrier free. Suitable for IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21874,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab238168 is the carrier-free version of
ab235445
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FoxJ1 also known as Forkhead Box J1 is a transcription factor that plays an important role in the regulation of gene expression. It is part of the forkhead family of transcription factors and has a molecular mass of approximately 44 kDa. FoxJ1 is expressed mainly in tissues with motile cilia such as the brain respiratory tract and reproductive organs. This expression pattern highlights its significance in tissues where ciliary movement is important for normal function.
Biological function summary
FoxJ1 is important in ciliogenesis the process of building cilia on the surface of cells. It acts as a master regulator by activating genes that code for ciliary components. This includes genes involved in the formation of the axoneme the core structure of cilia. FoxJ1 does not work alone; it functions within a network of other transcription factors and proteins to achieve effective cilia formation and movement. By controlling this process FoxJ1 ensures that ciliary structures develop and function correctly which is necessary for cellular motility and fluid movement across epithelial surfaces.
Pathways
FoxJ1 operates within critical pathways involved in cilia development and function. It integrates into the Wnt signaling pathway which is critical for embryogenesis and cell polarity. Additionally FoxJ1 interacts with the Notch signaling pathway. In these pathways it can relate to other transcription factors like Rfx3 which also influence cilia-related gene expression. FoxJ1 coordinates with these pathways to ensure precise regulation of cilia biogenesis and maintenance contributing to cellular processes that depend on functional cilia.
Deficient or malfunctioning FoxJ1 can lead to primary ciliary dyskinesia (PCD) and respiratory diseases. PCD results from impaired ciliary movement affecting respiratory tract function and fertility. Dysfunctional FoxJ1 expression can disrupt ciliary architecture connecting it to other proteins like DNAI1 which is often implicated in PCD. Abnormal FoxJ1 activity has also been linked to hydrocephalus where cerebrospinal fluid imbalances occur due to faulty cilia movement. In these conditions understanding FoxJ1's role provides insight into potential targets for therapeutic interventions.