Abcam, ab238338, Anti-PTCH2 antibody

Size: 100µg / 100µL
Rabbit Polyclonal PTCH2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTCH2 aa 750-1000.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PTCH2 aa 750-1000. The exact immunogen used to generate this antibody is proprietary information.Q9Y6C5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTCH2 also known as Patched 2 is a protein with a mass of approximately 145 kDa. It is a member of the Patched family of proteins and functions as a transmembrane receptor. PTCH2 is predominantly found on the surface of cells in tissues such as skin brain and testes. The protein serves an important role in regulating the signaling of the Hedgehog pathway by binding to its ligand Sonic Hedgehog which controls the activity of the smoothened (SMO) receptor.
Biological function summary
PTCH2 participates in the negative regulation of the Hedgehog signaling pathway. It forms a receptor complex with other proteins to maintain proper cell communication and growth control. PTCH2 is part of a larger complex that includes Patched 1 (PTCH1) contributing to embryonic development and tissue patterning. Its regulation of cellular growth and differentiation processes is critical for these activities.
Pathways
PTCH2 is a critical component of the Hedgehog signaling pathway and the development pathway. It closely interacts with PTCH1 and SMO in regulating signal transduction. Communication within these pathways is essential for tissue patterning and organogenesis. PTCH2's modulation of SMO results in downstream effects which impact the transcription of target genes controlling cell proliferation.
PTCH2 has a link to basal cell carcinoma and medulloblastoma. Its aberrant signaling and mutations may lead to uncontrolled cellular proliferation contributing to the onset of these cancers. The protein's interaction with PTCH1 also affects cancer susceptibility since both proteins can influence the progression and risk of developing tumors associated with the Hedgehog pathway.