Abcam, ab238446, Anti-MEF2A + MEF2C antibody [EPR19089-34] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MEF2C antibody. Carrier free. Suitable for ICC/IF, Flow Cyt (Intra), IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19089-34,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab238446 is the carrier-free version of
ab197070
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEF2A (Myocyte Enhancer Factor 2A) and MEF2C (Myocyte Enhancer Factor 2C) are transcription factors belonging to the MEF2 family. MEF2A has a molecular mass of approximately 55 kDa while MEF2C is around 51 kDa. Both MEF2A and MEF2C modulate gene expression through direct binding to regulatory DNA sequences. These proteins express in numerous tissues including muscle brain and vascular tissues indicating their extensive role in various cellular processes. MEF2A and MEF2C closely relate due to their structural similarities and functional overlap often working in concert with similar cofactors and regulatory proteins.
Biological function summary
MEF2A and MEF2C regulate multiple cellular processes especially in muscle differentiation and neuronal development. They frequently form complexes with other transcriptional regulators and play a significant role in the activation and repression of target genes. Through their interaction with the regulatory regions of DNA they help coordinate the transcriptional response necessary for cell growth development and survival. Their important involvement in muscle and nervous system development positions them as central players in maintaining proper cellular function during these processes.
Pathways
MEF2A and MEF2C serve as integral components in the MAPK and calcium signaling pathways. These pathways impact cellular response to environmental stimuli and regulate critical processes such as cell growth and differentiation. Interacting proteins like HDACs (histone deacetylases) further modulate the activity of MEF2A and MEF2C affecting their ability to regulate gene expression in response to various signals. This relationship is essential because it sustains the balance between activation and repression of target genes within these pathways.
MEF2A and MEF2C have significant implications in cardiovascular diseases and neurological disorders. Mutations or dysregulation in MEF2A often link to coronary artery disease highlighting its importance in cardiovascular health. Meanwhile MEF2C plays a role in autism spectrum disorders with abnormalities in its expression or function disrupting normal neuronal development. Both MEF2A and MEF2C interact with proteins such as GATA4 in the context of cardiac function and synaptic proteins for neuronal development respectively providing potential therapeutic targets for addressing the associated diseases and disorders.