Abcam, ab238761, Anti-TBCD/SSD1 antibody

Size: 100µL
Rabbit Polyclonal TBCD/SSD1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TBCD aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TBCD aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9BTW9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBCD also known as Tubulin Folding Cofactor D or SSD1 is a critical protein for tubulin folding and microtubule dynamics. It has a molecular mass of approximately 57 kDa and is located in various tissues with higher expression in the brain and testis. The protein works in combination with other tubulin cofactors to assist in proper β-tubulin folding and function which is important for maintaining cytoskeletal integrity.
Biological function summary
TBCD operates in conjunction with other proteins in a complex playing a significant role in microtubule biogenesis. It interacts with proteins such as TUBA1B to facilitate the proper folding and stability of β-tubulin. This process is essential for cell division and intracellular transport. Additionally it impacts neuronal structure by regulating axonal transport mechanisms influencing how neurons maintain their connections and communications.
Pathways
TBCD is integral to the microtubule dynamics pathway influencing cytoskeletal organization and function. It directly interacts with the microtubule-associated proteins like TUBG1 which is important in microtubule nucleation. TBCD also participates in the pathways regulating cell cycle and mitosis linked to proteins such as TUBB affecting how cells replicate and distribute genetic material during division.
Mutations or dysregulation in TBCD have associations with neurodegenerative diseases specifically Charcot-Marie-Tooth disease. This condition affects peripheral nerves where TBCD's interaction with β-tubulin is disrupted leading to improper neuronal function. Additionally TBCD connects to KIF1A a kinesin family member involved in axonal transport contributing to the pathology of certain neurodevelopmental disorders. These links highlight TBCD's importance in maintaining neural health and function.