Abcam, ab238763, Anti-LARP6 antibody

Size: 100µL
Rabbit Polyclonal LARP6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LARP6 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LARP6 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BRS8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LARP6 or La-related protein 6 is a member of the LARP family that plays a mechanical role in RNA-binding activities. It has a mass of about 63 kDa. LARP6 is expressed in various tissues with higher levels observed in the liver heart and skeletal muscle. Its main function is binding to specific messenger RNA (mRNA) motifs to regulate the stability and translation of these mRNAs.
Biological function summary
LARP6 is involved in the regulation of protein synthesis particularly influencing collagen biosynthesis. It often functions as part of a complex that binds to the 5' stem-loop structure of collagen mRNAs which helps stabilize them and facilitates their translation. LARP6 ensures the proper production of collagen proteins important for maintaining structural integrity in tissues.
Pathways
LARP6 functions within the collagen biosynthesis and secretion pathway. It closely interacts with proteins such as ribosome components to enhance mRNA translation efficiency. In the context of mRNA regulation LARP6 is significant for the post-transcriptional control of collagen production involving coordination with other RNA-binding proteins to affect the ribosomal engagement of target mRNAs.
LARP6 has been linked to fibrosis and certain connective tissue disorders. Abnormal expression or malfunction of LARP6 can lead to altered collagen synthesis contributing to disease progression. In fibrotic conditions disrupted LARP6 activity can impact collagen production pathways potentially interacting with proteins such as fibronectin which plays a role in extracellular matrix composition. Understanding LARP6's function and regulation could provide insights into treatments for these conditions.