Abcam, ab23942, Anti-Ganglioside asialo GM2 antibody

Size: 50µL
Rabbit Polyclonal Ganglioside asialo GM2 antibody. Suitable for ELISA, WB, TLC and reacts with Chemical samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Carrier free:No,
Applications:ELISA, TLC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:No cross-reaction with other carbohydrate epitopes.

Product details:
This product is a mix of IgG and IgM.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ganglioside asialo GM2 also known as GA2 is a biologically active glycolipid mass of approximately 1200 daltons. It typically resides in the outer layer of the plasma membrane of neuronal cells contributing to the structural integrity and functionality of cell membranes. In comparison with ganglioside GM2 asialo GM2 lacks sialic acid which affects its interactions and functions at the cellular level.
Biological function summary
This ganglioside plays an essential role in intercellular recognition and communication by participating in cell adhesion and signaling processes. It functions as part of glycoproduct complexes which impact the formation of signaling domains. These complexes influence synaptic stability and plasticity which are important for the functioning of the nervous system. Due to its structural properties asialo GM2 may also interact with proteins related to signaling pathways.
Pathways
Asialo GM2 influences neural signaling and development pathways. It associates with important cascade reactions including the PI3K/AKT signaling pathway which affects cell survival and metabolism. Additionally it potentially interacts with other glycolipids and proteins like integrins which play parts in cell adhesion and signal transmission. This interaction can modulate how cells respond to extracellular signals and maintain homeostasis.
Asialo GM2 relates notably to autoimmune neuropathies and neurodegenerative diseases. Anti-ganglioside antibodies targeting asialo GM2 may arise in conditions like Guillain-Barré syndrome an acute inflammatory disorder affecting the peripheral nervous system. These antibodies can damage neuronal gangliosides leading to nerve signal disruption. Additionally asialo GM2 may have impacts on the development of other neurodegenerative conditions where it interacts with neuropathy-associated proteins exacerbating disease progressions.