Abcam, ab239479, Anti-PGA5 antibody [C4]

Size: 100µg
Mouse Monoclonal PEPA5 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PGA5 aa 50-300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C4,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human, Pig,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PGA5 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.P0DJD9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
{PGA5} also known as pepsinogen 5 or progastricsin serves as an inactive precursor that gets converted into the active enzyme pepsin A. It possesses a molecular mass of approximately 42 kDa. PGA5 is primarily expressed in the gastric mucosa particularly in the chief cells of the stomach. The enzyme exhibits an acidic pH optimum and plays a role in the initial digestion of proteins in the stomach through its proteolytic activity.
Biological function summary
The role of PGA5 centers around protein digestion within the stomach. It is part of a larger protein complex interacting with other pepsinogens and hydrolyzing proteins into peptides. This function is integral in breaking down food proteins into absorbable units assisting in nutrient uptake and the general digestive process. Its activity depends upon the acidic environment present in the stomach where it becomes activated to exert its enzymatic function.
Pathways
PGA5 holds significance in the gastric digestion pathway. It interacts with related proteins such as other pepsinogens and chymosin forming an ensemble vital for protein digestion. PGA5 also crosses paths with the aspartic protease pathway which includes related proteins like pepsin C and cathepsin E. These pathways ensure the coordinated breakdown and processing of dietary proteins reflecting PGA5's contributions to gastrointestinal physiology.
PGA5 links to gastric ulcer and peptic ulcer disorders. Changes in PGA5 expression and activity can influence the protective mucus layer contributing to ulcer development. Additionally alterations in its levels are associated with gastric carcinoma where it may influence tumor behavior. Within these contexts PGA5 interacts with proteins such as H/K-ATPase in ulcer-related pathways and matrix metalloproteinases in cancer progression highlighting its importance in both digestive and pathological states.