Abcam, ab239503, Anti-Neurokinin A antibody [C1]

Size: 100µg
Mouse Monoclonal Protachykinin-1 antibody. Suitable for WB, IHC-P and reacts with Rat, Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAC1 aa 50 to C-terminus conjugated to Ovalbumin.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C1,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Rat, Human, Pig,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TAC1 aa 50 to C-terminus conjugated to Ovalbumin. The exact immunogen used to generate this antibody is proprietary information.P20366

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography.Purified from TCS., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurokinin A also known as substance K is a neuropeptide belonging to the tachykinin family. This peptide consists of 10 amino acids and has a molecular mass of approximately 1.13 kDa. Neurokinin A is expressed mainly in the central nervous system and the peripheral nervous system where it operates as a neurotransmitter and neuromodulator. The peptide shows significant expression in the brain especially in areas like the hippocampus striatum and neocortex. It is also present in peripheral tissues like the gastrointestinal tract and blood vessels.
Biological function summary
Neurokinin A influences numerous physiological processes including smooth muscle contraction and glandular secretion. It is not part of a complex but interacts directly with its receptor the neurokinin 2 receptor (NK2R) which is a G protein-coupled receptor. By binding to NK2R neurokinin A triggers various intracellular signaling cascades that affect cell functions such as proliferation migration and contraction. These actions make it an important player in modulating responses related to pain perception stress and inflammation.
Pathways
Neurokinin A participates in the tachykinin pathway which is important for signal transduction and neurotransmission in the nervous system. Within this pathway neurokinin A is closely related to other tachykinins like substance P and neurokinin B sharing cross-talk through their respective receptors. This interaction underlies many physiological responses such as vasodilation bronchoconstriction and modulation of pain and stress responses. Neurokinin A also plays a role in the inflammatory response pathway influencing immune cell activation and cytokine production.
Neurokinin A has been linked to asthma and inflammatory bowel disease. In asthma neurokinin A contributes to bronchoconstriction and airway inflammation through its action on NK2R and interaction with substance P. In inflammatory bowel disease it can exacerbate inflammation by affecting the motility and secretion of the gastrointestinal tract where it often works in tandem with other inflammatory mediators like cytokines therefore impacting disease progression. Understanding its role in these diseases could lead to targeted therapies that modulate neurokinin A's activity.