Abcam, ab23965, Anti-Ochratoxin A antibody [3C5]

Size: 50µg
Mouse Monoclonal Ochratoxin A antibody. Suitable for ELISA and reacts with Aspergillus samples. Cited in 2 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Ochratoxin A.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3C5,
Isotype:IgG1,
Light chain type:lambda,
Carrier free:No,
Reacts with:Aspergillus,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ochratoxin A is a mycotoxin that comes from mold species mainly Aspergillus and Penicillium. It is not a protein but acts through binding to serum proteins influencing biological processes. Ochratoxin A is classified as a secondary metabolite with a molecular weight of about 403.81 g/mol. It is expressed in food and beverages contaminated by fungal growth and also can be detected in human plasma when ingested. The presence of ochratoxin A leads to potential exposure risk through consumption of contaminated food products.
Biological function summary
Ochratoxin A exerts its effects by interfering with several cellular processes in the body particularly affecting kidney and liver function. Ochratoxin A affects protein synthesis and might disrupt DNA synthesis causing cellular stress and damage. It can also show interactions with cell membrane transporters and enzymes leading to altered redox balance inside cells. By these means ochratoxin A persistence in the body contributes to the toxicological effects that are studied under toxicology and pharmacology.
Pathways
Ochratoxin A participates in modulation of pathways involving oxidative stress and apoptosis. It interacts with key regulators in these pathways like cytochrome P450 enzymes which play a role in detoxification. Another impacted pathway is the aryl hydrocarbon receptor (AhR) signaling pathway which ochratoxin A might activate leading to changes in cellular metabolism and growth. These interactions suggest a connection with proteins like CYP1A1 known for involvement in drug metabolism and response to xenobiotics.
Ochratoxin A has a strong association with kidney-related diseases particularly nephrotoxicity which can lead to chronic kidney disease (CKD). It is also linked with liver dysfunction as the liver is a primary site of detoxification and metabolism. The presence of ochratoxin A can adversely affect proteins such as albumin which helps transport toxins in the blood and can signal the onset of these conditions. Understanding the impact of ochratoxin A on kidney and liver functions is vital in addressing risks related to mycotoxin exposure in humans.