Abcam, ab240392, Anti-PEG10/EDR antibody [EPR20051] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PEG10/EDR antibody. Carrier free. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20051,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, Flow Cyt (Intra), ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab240392 is the carrier-free version of
ab215035
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PEG10 also known as EDR2 is a paternally expressed imprinted gene that encodes the PEG10 protein. The PEG10 protein has a molecular mass of approximately 150 kDa. It shows expression most notably in the placenta during development but also in other tissues like the liver and brain. The protein contains two open reading frames that produce different products via a frameshift mechanism similar to retroviral proteins.
Biological function summary
The PEG10 protein plays multiple roles especially in cell proliferation apoptosis inhibition and promoting cell survival. It can be part of larger protein complexes that modulate cellular responses to stress and developmental cues. The protein's multifaceted activities are important during embryogenesis where it supports trophoblast development and placental formation.
Pathways
PEG10 interacts with signaling cascades such as the TGF-beta signaling pathway and is involved in cell cycle regulation. PEG10 works alongside proteins like paternally expressed genes that connect with TGF-beta pathways influencing cellular differentiation and growth. Its integration in these pathways highlights its role in managing cellular environments and responses to cellular stress signals.
PEG10 expression over-activation has associations with cancer especially hepatocellular carcinoma and pancreatic cancer. In these contexts PEG10 interacts with proteins like H3L3 contributing to oncogenic pathways that drive tumor cell proliferation and survival. Elevated levels of PEG10 can serve as potential biomarkers for certain cancers suggesting their role in disease progression and possible therapeutic targeting.