Abcam, ab240959, Anti-Oct-1 antibody [EPR16570] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Oct-1 antibody. Carrier free. Suitable for IP, IHC-P, WB and reacts with Human, Rat, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16570,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab240959 is the carrier-free version of
ab178869
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Oct-1 also known as POU domain class 2 transcription factor 1 (POU2F1) is a transcription factor characterized by its POU-specific domain. The molecular weight of Oct-1 is approximately 76 kDa. It is expressed widely across different tissues with high levels found in lymphoid organs and epithelial cells. It binds to octamer motifs in the promoters of target genes regulating their transcription. Oct-1 plays a role in the cell cycle development and immune response.
Biological function summary
Oct-1 participates in the regulation of gene expression by influencing RNA polymerase II. It is not part of a larger protein complex for its primary function but it does interact with other cofactors. Oct-1 is essential for maintaining the expression of housekeeping genes as well as for the induction of specific genes during external stimuli responses. By modulating cellular responses Oct-1 helps in the regulation of cells' growth differentiation and adaptation to stress.
Pathways
Oct-1 is involved in pathways related to stress responses and immune system function. It significantly influences the transcriptional activation of genes associated with the stress response pathway. Oct-1 associates with proteins like c-Myc and others within these pathways which contribute to the regulation of cell proliferation and apoptosis. Its role in these pathways highlights its involvement in cellular homeostasis and survival.
Oct-1's dysregulation connects to the pathogenesis of various conditions including cancer and autoimmune diseases. Changes in Oct-1 activity have been observed in several cancers affecting tumorigenesis and progression. It interacts with proteins like Bcl-2 in the context of cancer impacting cell survival mechanisms. In autoimmune diseases such as lupus altered Oct-1 function can lead to inappropriate immune responses partly through interaction with transcription factors like NF-κB. Understanding the role of Oct-1 can help in developing targeted therapeutic strategies for these disorders.