Abcam, ab241197, Anti-IQ motif containing B1 antibody

Size: 100µg
Rabbit Polyclonal IQ motif containing B1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IQCB1 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IQCB1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15051

Product details:
ab241197 has not performed satisfactorily when used for WB of IQ motif containing B1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of IQ motif containing B1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to IQ motif containing B1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IQ motif containing B1 also known as IQCB1 or NPHP5 is a protein that functions mechanically as a part of cellular pathways involving microtubule dynamics. This protein has an approximate mass of 69 kDa and is widely expressed in various tissues with higher levels noted in the retina and kidney. The function of IQCB1 is closely related to its role in intracellular transport and sensory cilia signaling.
Biological function summary
IQ motif containing B1 plays an important role in the ciliary transition zone which is an important component in cilia formation and function. This protein is part of a protein complex known as the nephronophthisis module where it collaborates with other proteins to maintain ciliary structural integrity. Defects or mutations in IQCB1 may disrupt this module highlighting its significance in normal cellular operations.
Pathways
The IQ motif containing B1 is involved in the ciliogenesis and cilia function pathways. In these pathways it interacts with proteins such as NPHP6 (also known as CEP290) to regulate ciliary assembly and ensure proper signal transduction. IQCB1's function is essential for the proper maintenance of these pathways which are critical for sensory perception and cellular communication.
Mutations in IQ motif containing B1 are linked to conditions such as nephronophthisis and retinitis pigmentosa. The protein's interaction with other proteins like RPGR which is associated with retinitis pigmentosa emphasizes its role in multi-systemic diseases affecting the kidneys and eyes. Understanding the function and interaction of IQCB1 with these proteins provides insights into the mechanisms underlying these disorders and may guide future therapeutic strategies.