Abcam, ab241367, Anti-eIF3l antibody

Size: 100µg
Rabbit Polyclonal EIF3L antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EIF3L aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EIF3L aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9Y262

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241367 was affinity purified using an epitope specific to eIF3l immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The eukaryotic translation initiation factor 3 subunit L (eIF3l) also known as eIF-3 eta plays an essential role in the initiation of protein synthesis by facilitating the assembly of the pre-initiation complex on the mRNA. This protein with a mass of approximately 44 kDa is ubiquitously expressed across various tissues indicating its importance in overall cellular processes. As a component of the eIF3 complex it helps in regulating the translation initiation step which is a critical control point in protein synthesis.
Biological function summary
EIF3l interacts with other components of the eIF3 complex to ensure the proper function of the translation machinery. This subunit as part of the eIF3 complex helps in the recruitment of the 40S ribosomal subunit to the 5' mRNA cap structure which is a necessary step for the initiation of translation. The eIF3 complex consists of multiple subunits and eIF3l specifically plays a role in the stability and function of this complex contributing to the efficiency and fidelity of protein biosynthesis.
Pathways
EIF3l participates heavily in the translation initiation pathway which is a major step in gene expression regulation. This process influences many other pathways involving cell growth and proliferation such as the mTOR signaling pathway. In this context eIF3l interacts with other elements of the translation machinery such as the protein eIF4F which together impact processes like cap-dependent translation and cellular response to nutrient availability.
EIF3l has connections to cancer and neurodegenerative diseases indicating its significance in both proliferation-related and degenerative pathways. Abnormal expression or malfunction of eIF3l can potentially lead to disorders such as specific types of cancer due to its role in uncontrolled cell growth and protein synthesis. In addition eIF3l's interaction with key proteins like mTOR connects it to pathways involved in oncogenesis and cancer cell survival strategies further highlighting its clinical importance.