Abcam, ab241489, Anti-LARP4 antibody

Size: 100µg
Rabbit Polyclonal LARP4 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human LARP4 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LARP4 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q71RC2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to LARP4 immobilized on solid support, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LARP4 also known as La-related protein 4 plays a role in RNA biology. LARP4 is a cytoplasmic protein with a mass of approximately 80 kDa. It is expressed in various tissues with notable presence in liver kidney and muscle tissues. LARP4 interacts with specific RNA motifs influencing RNA stability and translation. This protein associates with poly(A) binding proteins highlighting its role in RNA metabolism.
Biological function summary
LARP4 modulates RNA stability and translation efficiency. It associates with the poly(A) ribonucleoprotein complex where it influences mRNA turnover and translation rates. Through these interactions LARP4 supports proper protein synthesis aligning with cellular needs. In addition to impacting RNA stability LARP4 interacts with other proteins involved in ribosome recruitment and translation initiation further cementing its role in post-transcriptional regulation.
Pathways
LARP4 integrates into pathways affecting RNA processing and protein synthesis. It links closely with the mTOR signaling pathway which is important for cell growth and protein synthesis regulation. Within this pathway LARP4 interacts with proteins like PABP highlighting its contribution to mRNA translation control. Furthermore the interplay with mTOR signaling suggests a broader effect on cellular metabolism beyond RNA processing.
LARP4 has connections to cancer and muscular dystrophy. Its role in RNA stability links it to oncogenic processes where dysregulation might contribute to tumorigenesis. In some cancers aberrant LARP4 expression associates with increased tumor growth potentially through altered mRNA turnover. Additionally links between LARP4 and muscle protein synthesis issues connect it to muscular dystrophy pathogenesis wherein its interaction with dysregulated proteins impacts muscle integrity.