Abcam, ab241505, Anti-Pan2 antibody

Size: 100µg
Rabbit Polyclonal PAN2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PAN2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PAN2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q504Q3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to Pan2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan2 is a protein also known as PAN2 poly(A) specific ribonuclease or PAN2-1. It functions as an essential component of the Pan2-Pan3 deadenylation complex responsible for shortening poly(A) tails of mRNAs. This action plays an important role in mRNA turnover and regulation of gene expression. Pan2 has a mass of approximately 162 kDa. Scientists have observed its expression in various tissues with notable presence in the cytoplasm where it interacts with other elements of the mRNA decay machinery.
Biological function summary
The targeted actions of Pan2 facilitate the regulation of mRNA stability which influences protein synthesis rates. Pan2 is part of the Pan2-Pan3 complex where it collaborates with Pan3 to catalyze the initial steps of deadenylation. This process is critical for normal cellular function affecting mRNA lifespan and its translation into protein. In this complex Pan2 provides the catalytic activity while Pan3 enhances its function and anchors the complex to the mRNA substrate.
Pathways
The function of Pan2 in mRNA degradation places it in the mRNA surveillance pathway and the general mRNA decay pathway. These pathways ensure proper regulation and quality control of mRNA within the cell. Pan2 works closely with the CCR4-NOT complex a significant player in mRNA deadenylation. These interactions allow for efficient control over gene expression by modulating the stability and availability of mRNA for translation.
The dysregulation of Pan2 has been implicated in cancer and neurodegenerative diseases. Abnormal mRNA decay processes related to malfunctioning Pan2 can lead to uncontrolled cell growth and tumorigenesis. Additionally Pan2 malfunction may connect to proteins like NOT1 influential in other disorders for instance neurodegeneration. These associations highlight the protein's potential role in pathologies necessitating continued research for better understanding and treatment strategies.