Abcam, ab241574, Anti-QRICH1 antibody

Size: 100µg
Rabbit Polyclonal QRICH1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human QRICH1 aa 250-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human QRICH1 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.Q2TAL8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241574 was affinity purified using an epitope specific to QRICH1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
QRICH1 also known as Glutamine-rich protein 1 is a protein that plays an essential role in transcriptional regulation. It has a molecular mass of approximately 91 kDa. This protein is highly expressed in human tissues such as the heart liver and brain. It functions as a transcription factor influencing the expression of genes by binding to specific DNA regions. QRICH1 contains a glutamine-rich region which is typical for transcription factors that assist in the regulation of gene expression.
Biological function summary
QRICH1 modulates cellular processes that involve gene expression. It is part of the transcriptional machinery complex interacting directly with other transcriptional regulators and co-activators. This interaction influences cellular activities such as proliferation differentiation and stress responses. QRICH1 regulates genes involved in cell cycle control and apoptosis affecting how cells respond to various internal and external signals. Its biological role makes it an important target for understanding gene regulatory networks.
Pathways
QRICH1 plays a role in pathways significant to cellular stress responses and apoptosis. It interacts with proteins such as p53 and E2F1 which are important in these pathways. QRICH1 helps mediate cellular responses to DNA damage working alongside p53 in the apoptotic signaling pathway. Additionally its interaction with transcription factors such as E2F1 highlights its involvement in cell cycle regulation and the balance between cell survival and apoptosis.
QRICH1 has connections to cancer and neurodegenerative diseases. In cancer alterations in QRICH1 expression or function can lead to uncontrolled cell proliferation due to its role in regulating genes tied to the cell cycle and apoptosis. Its interaction with p53 and E2F1 further points to its involvement in tumorigenesis when dysregulated. In neurodegenerative disorders QRICH1's expression in the brain tissue suggests it might play a role possibly connected to stress response pathways related to neurodegeneration. Understanding its function could uncover targets or markers for therapeutic interventions in these diseases.