Abcam, ab241996, Anti-Kir6.1/KCNJ8 antibody [S366-60]

Size: 100µg
Mouse Monoclonal Kir6.1/KCNJ8 antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat ATP-sensitive inward rectifier potassium channel 8 aa 300 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:S366-60,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat ATP-sensitive inward rectifier potassium channel 8 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q63664

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kir6.1 also known as KCNJ8 is an integral part of a potassium channel complex. It forms the inwardly rectifying potassium channel (Kir) family that allows potassium ions to flow into cells. The Kir6.1 channel often a part of the larger ATP-sensitive potassium channels (K_ATP channels) regulates cellular membrane potentials. The protein mass of Kir6.1 is approximately 45 kDa. You can find Kir6.1 expressed in various tissues including the heart skeletal muscle and smooth muscle as well as in pancreatic beta cells.
Biological function summary
Kir6.1 plays a significant role in linking cellular energy status to membrane excitability through the modulation of potassium ion conductance. It forms a complex with SUR2 (sulfonylurea receptor 2) subunits collectively constituting the K_ATP channel complex. This channel complex senses changes in intracellular ATP levels and its activity influences insulin secretion in the pancreas and vascular tone in smooth muscle. By coupling cellular metabolic status to the ion channel activity Kir6.1 contributes critically to cellular homeostasis.
Pathways
Kir6.1 channels integrate into several important biological systems. Notably the K_ATP channels participate in the cardiac muscle's ischemic conditioning pathway helping protect cells against nutrient deprivation. These channels also engage in the insulin signaling pathway affecting glucose homeostasis and energy metabolism. The interaction with other proteins like SUR2 and Kir6.2 indicates the complex role Kir6.1 plays in these signaling cascades and its indispensable function in metabolic regulation.
The Kir6.1 channel has associations with cardiovascular diseases such as hypertension due to its involvement in vascular tone regulation. Abnormalities in Kir6.1 function can also contribute to disorders like neonatal diabetes linked to defects in insulin secretion due to channel dysfunction. Kir6.1 has connections with the SUR2 protein in these conditions given their partnership in the K_ATP channel complex. Studying these associations helps understand Kir6.1's influence on disease development and potential therapeutic interventions.