Abcam, ab241997, Anti-Spectrin beta chain, brain 3 antibody [S393-2]

Size: 100µg
Mouse Monoclonal Spectrin beta chain, brain 3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPTBN4 aa 1600-1850.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:S393-2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPTBN4 aa 1600-1850. The exact immunogen used to generate this antibody is proprietary information.Q9H254,
Specificity:Does not cross react with other Beta-spectrins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Spectrin beta chain brain 3 also known as SPTBN3 is a cytoskeletal protein that belongs to the spectrin family. It displays a mass of approximately 271 kDa. This protein is ubiquitously expressed in the brain where it contributes to the cytoskeletal framework by cross-linking actin filaments. Additionally it plays a structural role in maintaining the integrity and flexibility of cell membranes. SPTBN3 is essential for proper neuronal function by stabilizing membrane proteins and supporting intracellular transport.
Biological function summary
Spectrin beta chain brain 3 functions as part of the spectrin cytoskeleton which involves binding with alpha spectrin to form a heterodimer further assembling into a tetramer structure. This spectrin network supports the cell's structural organization and is critical in processes like signal transduction and protein targeting. Its presence in neurons aids in maintaining the shape and polarity required for the proper functioning of complex neural networks. The spectrin-based cytoskeleton interacts with numerous other proteins to modulate various cellular activities.
Pathways
SPTBN3 holds relevance in the regulation of the MAPK signaling pathway and the actin cytoskeleton pathway. The MAPK pathway is important for transmitting extracellular signals to responses like cell growth and differentiation. As a result SPTBN3 interacts with proteins such as MAP2K1 facilitating proper signal propagation. In the actin cytoskeleton pathway SPTBN3 maintains cellular morphology and mechanical support working with proteins like actin beta contributing to various morphological processes.
Spectrin beta chain brain 3 connects to neurodegenerative disorders and epilepsy. Abnormalities in SPTBN3 expression or function may result in neuronal instability leading to conditions like Alzheimer's disease due to disrupted cytoskeletal dynamics. Changes in its interaction with proteins such as tau and amyloid precursor protein can exacerbate pathological processes. Its role in epilepsy emerges through dysfunctional synaptic stability and neuronal signaling emphasizing SPTBN3's importance in maintaining normal neurological function.