Abcam, ab242127, Anti-FOXP4 antibody [EPR22714-2]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal FOXP4 antibody. Suitable for IHC-P, ICC/IF, IP, WB, IHC-Fr, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22714-2,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-Fr, ICC/IF, IP, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXP4 also known as Forkhead Box P4 is a transcription factor belonging to the FOX protein family. Its molecular mass approximately 80 kDa. It is expressed in various tissues with high expression levels observed in lung kidney and prostate. The protein binds to DNA and regulates the transcription of genes involved in development and differentiation.
Biological function summary
FOXP4 plays an important role in regulating developmental processes particularly in the central nervous system and lung tissue. It often functions as part of a complex that includes other FOXP proteins like FOXP1 and FOXP2 which share a conserved DNA-binding forkhead domain. These proteins collaborate to regulate genes important for cell differentiation and organogenesis.
Pathways
The transcriptional activity of FOXP4 integrates into significant signaling pathways such as the Wnt signaling and TGF-beta pathways. These pathways govern processes like cellular growth and differentiation. FOXP4 interacts with other FOX proteins including FOXP1 to modulate gene expression patterns important for these pathways.
Research indicates that FOXP4 is associated with lung cancer and neurodevelopmental disorders. Its dysregulation can affect cellular processes linked to tumorigenesis and cognitive development. FOXP4’s involvement with other proteins such as FOXP1 highlights its role in modulating gene networks that when disrupted can contribute to disease pathogenesis.