Abcam, ab242217, Recombinant human IFNA13 protein (Active)

Size: 100µg
Recombinant human IFNA13 protein (Active) is a Human Full Length protein, in the 24 to 189 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, HPLC.
Key facts
Purity:>95% SDS-PAGE,
Endotoxin level:< 1 EU/µg,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:FuncS, HPLC, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.0 x 108 IU/mg.,
Accession:P01562,
Animal free:No,
Carrier free:No,
Species:Human,
Reconstitution:Reconstitute in water or 0.1% BSA aqueous buffer,
Storage buffer:Constituents: PBS, 4% Mannitol, 1% Human serum albumin

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFN-α13 also known as Interferon Alpha-13 is a member of the type I interferons. This protein plays an important role in the immune response against viral infections. Interferon Alpha-13 has a molecular mass of approximately 22 kDa and is widely expressed in tissues involved in the immune response especially in leukocytes. Due to its role in antiviral activity IFN-α13 is an important subject of study in immunology and virology.
Biological function summary
Interferon Alpha-13 contributes to the antiviral defense mechanism by inducing the expression of genes that hinder viral replication. It is part of the larger interferon protein family which acts through the JAK-STAT signaling pathway. When activated IFN-α13 promotes the production of various antiviral enzymes and enhances the ability of the immune cells to detect and destroy infected cells. It triggers the expression of MHC class I molecules and activates natural killer cells.
Pathways
IFN-α13 interacts with the JAK-STAT pathway to mediate the immune response. In this pathway Janus kinase (JAK) activates signal transducer and activator of transcription (STAT) proteins to induce gene expression for antiviral and immunomodulatory proteins. It is also involved in the regulation process of the adaptive immune response through connections with IFN receptors contributing further to limiting pathogen spread. Other important proteins related to this pathway include STAT1 and STAT2 which cooperate to initiate the transcription of IFN-stimulated genes.
IFN-α13 has a significant relationship with chronic viral infections and certain autoimmune conditions. It plays a part in the body's natural defense against Hepatitis C virus where its role in promoting antiviral states within cells becomes important. Additionally an overactive interferon system including proteins like IFN-α2 and IFN-α13 can contribute to autoimmune disorders such as systemic lupus erythematosus (SLE). Studies continue to explore its dual role both in aiding antiviral defense and in the potential activation of autoimmune pathways.