Abcam, ab242376, Anti-LAPTM4B antibody [CL5289]

Size: 100µL
Mouse Monoclonal LAPTM4B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LAPTM4B aa 200-250.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CL5289,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LAPTM4B aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q86VI4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAPTM4B also known as Lysosomal Protein Transmembrane 4 Beta is a membrane protein involved in endolysosomal trafficking. This protein has a molecular mass of around 27 kDa. LAPTM4B is highly expressed in liver kidney and placenta tissue with notable expression in several types of solid tumors. Its location in endosomes and lysosomes suggests a role in cellular cargo sorting and transport processes.
Biological function summary
LAPTM4B is essential for regulating lysosomal function and intracellular signaling. This protein forms part of a complex with other lysosomal associated proteins and is involved in the regulation of lysosome positioning and signaling pathways. By modulating lysosome function LAPTM4B affects cellular processes like growth proliferation and apoptosis playing an important role in cell survival and homeostasis.
Pathways
This protein participates in the PI3K/Akt and MAPK signaling pathways which are critical for cell growth and survival. LAPTM4B interacts with proteins such as EGFR (Epidermal Growth Factor Receptor) and mTOR (mammalian target of rapamycin) which facilitate its role in these pathways. Its involvement in these pathways contributes to its regulatory function in cell survival and metabolism.
Researchers link LAPTM4B to cancer and osteoporosis. Overexpression of LAPTM4B has been observed in various types of cancers including liver and breast cancer where it may contribute to tumor growth and metastasis. In osteoporosis LAPTM4B interacts with proteins such as Cathepsin K which are involved in bone resorption suggesting its potential role in bone metabolism and health.