Abcam, ab24294, Anti-SUC1 antibody [AA10.2]

Size: 50µg
Mouse Monoclonal CKS1 antibody. Suitable for IHC, IP, WB and reacts with Schizosaccharomyces pombe samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:AA10.2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Schizosaccharomyces pombe,
Applications:IP, IHC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab24294 can be used exclusively to capture CDK1 complexes from various cell lines and egg extracts.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SUC1 protein also known as CKSHS1 has a molecular mass of approximately 13 kDa. It is mainly expressed in yeast cells particularly in the fission yeast Schizosaccharomyces pombe. Mechanically SUC1 functions as a regulatory protein that plays a role in cell cycle control by interacting with cyclin-dependent kinases (CDKs). This interaction modulates the activity of CDKs influencing their ability to phosphorylate target substrates necessary for cell cycle progression.
Biological function summary
SUC1 acts as a modulator of the cell cycle. The protein operates as part of a complex binding to and regulating CDKs which are important for the control of cell division. It ensures proper cell cycle transitions by affecting CDK activity which then governs cellular processes like DNA replication and mitosis. SUC1's role in stabilizing these interactions is indispensable for maintaining cell cycle fidelity and therefore regulates cellular proliferation.
Pathways
SUC1 integrates into the cell cycle regulation and mitotic pathways. It associates with the Cyclin-CDK complex impacting pathways that ensure accurate cell cycle checkpoints and DNA repair mechanisms. SUC1 relates specifically to pathways involving CDK1 and CDC2 proteins which are foundational for driving the cells through mitosis. The presence of SUC1 in these pathways allows it to act as an important control point influencing the stability and function of CDK complexes.
Dysregulation of SUC1 function can link to cancer and yeast cell cycle disorders. Aberrant modulation of CDK activity partly due to SUC1 malfunction disrupts the cell cycle potentially leading to uncontrolled cell proliferation seen in cancer. SUC1 interaction with CDK1 also implicates it in disorders linked to disrupted cell division and genomic instability. This connection highlights potential for targeted therapies that aim to restore normal cell cycle regulation through the modulation of SUC1 function.