Abcam, ab243139, Anti-LMO 4 antibody [20F8]

Size: 100µg / 1mg
Rat Recombinant Monoclonal LMO4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:20F8,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMO4 also known as LIM-only protein 4 is a nuclear protein that plays important roles in various cellular functions. It has a molecular weight of approximately 23 kDa. LMO4 is expressed in several tissues including the brain lung and breast. It belongs to the LIM-domain family characterized by two LIM domains that facilitate protein-protein interactions but lack a DNA-binding domain. This makes LMO4 a regulator of transcription by forming complexes with other proteins.
Biological function summary
LMO4 serves as a transcriptional regulator in multiple cell types. It forms complexes with other co-regulators and transcription factors. For instance LMO4 interacts with LDB1 (LIM domain-binding protein 1) and SSDP1 (Single-stranded DNA-binding protein 1) which are part of a larger transcriptional complex. Through these interactions LMO4 influences the expression of genes critical for tissue development and cellular differentiation highlighting its diverse biological functions.
Pathways
LMO4 participates in signaling pathways like the BMP (Bone Morphogenetic Protein) and ER (Estrogen Receptor) pathways. In BMP signaling it associates with SMAD proteins to modulate gene transcription. Within the ER pathway LMO4 interacts with co-activators such as SRC family proteins impacting estrogen-responsive gene expression. This shows that LMO4 can integrate into pathways influencing cell growth and differentiation.
LMO4 has significant connections to breast cancer and neurological disorders. Its overexpression correlates with poor prognosis in breast cancer where it interacts with proteins like ERα (Estrogen Receptor alpha) to enhance tumor progression. In neurological disorders abnormal expression of LMO4 has been linked to developmental issues including cognitive dysfunction. The interactions with other transcriptional regulators highlight its potential involvement in these conditions.