Abcam, ab243190, Anti-Major outer membrane protein antibody [cj-01]

Size: 100µg
Mouse Monoclonal Major outer membrane protein antibody. Suitable for WB and reacts with Campylobacter coli, Campylobacter jejuni samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Campylobacter jejuni protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:cj-01,
Isotype:IgM,
Carrier free:No,
Reacts with:Campylobacter coli, Campylobacter jejuni,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from TCS. Filter sterilized., Storage buffer-pH: 6.5 - 8.5Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Major outer membrane protein (MOMP) also known as the Cj-01 outer membrane protein A is an essential structural component of the bacterial outer membrane. MOMP weighs approximately 40 kDa and is expressed on the surface of gram-negative bacteria playing a critical role in their permeability and structural integrity. The protein facilitates the transport of small molecules and ions across the membrane functioning as a selective porin. MOMP is commonly studied in species such as Chlamydia trachomatis and Campylobacter jejuni where it constitutes a significant part of the outer membrane architecture.
Biological function summary
MOMP impacts processes beyond structural support. In Chlamydia it contributes to immune evasion and is a target for host antibody responses. The protein forms part of a larger outer membrane complex that allows the bacteria to maintain a semi-permeable barrier. Its unique beta-barrel structure permits selective permeability while providing resilience which is vital for bacterial survival in harsh environments. It is also involved in maintaining membrane stability and resisting hostile factors such as detergents and bile salts.
Pathways
The Major outer membrane protein participates in important biochemical pathways like the transport and immune modulation within gram-negative bacteria. MOMP interacts with bacterial secretion pathways being related to proteins involved in nutrient uptake and waste processing. It works in conjunction with ATP-binding cassette (ABC) transporters facilitating essential transport processes that sustain bacterial life. These pathways have evolutionary importance enabling the microorganism's adaptation and resilience to changes in the host environment.
The presence and function of Major outer membrane protein are closely linked to infectious diseases such as trachoma and gastroenteritis. In Chlamydia trachomatis MOMP is associated with trachoma a leading cause of blindness and is a major antigen for vaccine development efforts. In Campylobacter jejuni it correlates with gastroenteritis where the protein's structure allows for immune system evasion. The protein's interaction with antibodies in these diseases highlights potential therapeutic targets linking it to other bacterial proteins involved in immune response and pathogenesis.