Abcam, ab243570, Anti-SPERT antibody

Size: 100µL
Rabbit Polyclonal SPERT antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CBY2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CBY2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q8NA61

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPERT also known as sperm-associated antigen 9 (SPAG9) weighs approximately 40 kDa. This protein mainly finds expression in testis tissue but also appears in other tissues like breast and prostate albeit at lower levels. SPERT localizes in the cytoplasm and nucleus of cells suggesting its role in various cellular processes.
Biological function summary
SPERT interacts with components critical for spermatogenesis and fertilization processes. It forms part of a protein complex that regulates specific functions during sperm development. Through its associations SPERT influences microtubule binding and possibly affects the integrity and motility of sperm cells. These functions highlight its important role in male fertility.
Pathways
Researchers connect SPERT to the JNK signaling pathway which regulates stress responses and apoptosis. In this context SPERT modulates interactions with proteins like c-Jun N-terminal kinases (JNKs) playing a role in cell survival and apoptosis. SPERT’s involvement in regulating kinase activity links it to MAPK pathways which further emphasize its influence on cellular growth and differentiation.
SPERT has been implicated in certain reproductive disorders such as male infertility. Abnormal expression or mutations in SPERT may impact sperm function linked to disrupted spermatogenesis. Additionally irregular SPERT expression correlates with breast cancer possibly through its interactions affecting cellular pathways driven by JNK and MAPK proteins. Understanding these links helps recognize SPERT's role in pathological conditions and may guide future therapeutic strategies.