Abcam, ab243700, Anti-ZNF480 antibody

Size: 100µL
Rabbit Polyclonal ZNF480 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF480 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF480 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q8WV37

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF480 also known as Zinc Finger Protein 480 is a transcription factor that works through binding to specific DNA sequences. It consists of multiple C2H2-type zinc finger motifs. The mass of ZNF480 is approximately 86 kDa. This protein is expressed in various tissues including the liver kidney and heart suggesting its involvement in diverse physiological processes.
Biological function summary
ZNF480 regulates transcription by acting as a modulator of gene expression. It interacts with DNA to influence the transcriptional activity also indicating a potential role in chromatin remodeling. ZNF480 might be part of larger protein complexes that manage transcription processes. Through its function ZNF480 assists in cellular differentiation and proliferation impacting cell fate decisions.
Pathways
ZNF480 influences gene regulation networks involved in cell growth and differentiation. It is connected with the Notch signaling pathway which is important for many developmental processes. ZNF480 might interact with other proteins like RBPJ an integral component of the Notch pathway to execute its regulatory roles.
Researchers have linked ZNF480 to certain cancers such as breast cancer where it might affect tumor cell proliferation. They have also associated ZNF480 with neurological disorders potentially through disrupted transcriptional regulation involving other proteins like REST which is important in neuronal gene expression modulation. Understanding ZNF480's involvement in these diseases could provide targets for therapeutic interventions.