Abcam, ab244215, Anti-USP46 antibody [CL0364]

Size: 100µL
Mouse Monoclonal USP46 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP46 aa 100-250.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CL0364,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP46 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.P62068,
Epitope:Binds to an epitope located within the peptidesequence TNETRCLNCE as determined by overlapping synthetic peptides.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP46 also known as Deubiquitinating enzyme 46 is an important player in the process of removing ubiquitin molecules from proteins. This enzyme belonging to the ubiquitin-specific protease family has a molecular mass of approximately 41 kDa. USP46 is widely expressed in various human tissues but significant levels are observed in the brain indicating its importance in neurological processes. Its deubiquitination activity modulate protein turn-over stability and signaling pathways influencing diverse cellular functions.
Biological function summary
USP46 modulates the ubiquitin-proteasome system by removing ubiquitin from substrate proteins which impacts their degradation or activity. It exists as part of a larger protein complex interacting with proteins such as WDR20 which enhance its activity. This interaction allows USP46 to regulate protein homeostasis within neurons and other cells. In the nervous system its activity supports synaptic function and plasticity contributing to effective neural communication and cognitive processes.
Pathways
USP46 mainly acts within the ubiquitin-proteasome pathway an essential mechanism for protein degradation and regulation. It interacts with proteins like UBE3A and UCH-L1 which are important for maintaining protein balance and cellular stress responses. Another important pathway involving USP46 is the neural plasticity and signaling pathway where it helps in regulating the degradation of synaptic proteins contributing to learning and memory.
USP46 has been linked to neurological disorders such as depression and schizophrenia. Abnormalities in its function or expression levels could disrupt normal synaptic activity and protein homeostasis. The enzyme shows a connection with proteins like GSK3β and DISC1 which are implicated in these disorders. Targeting USP46 activity holds potential in developing new therapeutic strategies for such neuro-psychiatric conditions offering avenues for further research and innovation in medical science.