Abcam, ab244271, Anti-EPS8 antibody

Size: 100µL
Rabbit Polyclonal EPS8 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Epidermal growth factor receptor kinase substrate 8 aa 400-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Epidermal growth factor receptor kinase substrate 8 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.Q12929

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPS8 also known as Epidermal Growth Factor Receptor Pathway Substrate 8 functions as an adaptor protein that regulates actin cytoskeleton remodeling. This protein has a mass of approximately 97 kDa. EPS8 is expressed in a variety of tissues including those in the brain skin and digestive tract. EPS8 interacts with other proteins at the cellular membrane and in the cytosol playing a role in transmitting signals from receptors on the cell surface to the actin cytoskeleton inside the cell.
Biological function summary
EPS8 influences cellular behaviors such as migration adhesion and proliferation. It associates with a multiprotein complex that includes other signaling molecules such as SOS1 and ABI1. Through these interactions EPS8 contributes to the regulation of actin filament formation which is important for cell movement and shape. The rigid structure and dynamics of the actin cytoskeleton mainly regulated through EPS8 activity impact various cellular functions.
Pathways
EPS8 plays a significant role in the epidermal growth factor receptor (EGFR) signaling pathway and the Ras signaling pathway. Within these pathways EPS8 modulates downstream signaling that affects processes like cell growth and survival. It interacts with other proteins such as actin-binding proteins and the SH3 domain-containing proteins which further connect it to diverse signaling cascades.
Disruptions in EPS8 expression or function have associations with cancer progression particularly in colorectal and breast cancers. EPS8 overexpression can lead to increased metastasis and poor prognosis in these cancers. The interaction of EPS8 with proteins like EGFR and other components of signaling pathways highlights its involvement in oncogenic processes. Research into EPS8 offers potential therapeutic strategies in targeting cancers that exhibit aberrant EPS8 activity.