Abcam, ab244331, Anti-Robo2 antibody

Size: 100µL
Rabbit Polyclonal ROBO2 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ROBO2 aa 900-1100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ROBO2 aa 900-1100. The exact immunogen used to generate this antibody is proprietary information.Q9HCK4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Robo2 also known as Roundabout Homolog 2 is a protein with significant roles in axon guidance. This protein has a molecular mass of approximately 147 kDa and is a member of the Robo receptor family. It is primarily expressed in the nervous system including areas such as the spinal cord brain and olfactory bulb. Robo2 interacts with Slit proteins to mediate the repulsive guidance of axons which is fundamental for the formation of connections in the developing nervous system.
Biological function summary
Robo2 functions in the nervous system to guide axons and establish neuron networks. It plays a role in cellular processes like migration and axonal pathfinding ensuring proper connectivity. Robo2 operates as a receptor and does not form part of a larger complex by itself but it does have interactions with other molecules. By binding with Slit proteins Robo2 helps repel axons away from certain areas aiding in the clear mapping of axonal trajectories.
Pathways
Robo2 participates in axon guidance pathways including the Slit-Robo signaling pathway. This pathway is fundamental in nervous system development and is responsible for steering axonal growth direction. Within these pathways Robo2 displays interaction with proteins like neuron-specific Slit proteins which are secreted molecules helping to establish gradients that direct axon shrinkage or extension.
Robo2 is linked to conditions like congenital heart defects and urofacial syndrome. Abnormal expression or mutations in the Robo2 gene may disrupt normal axonal pathfinding leading to developmental issues. Robo2 has also shown associations with other proteins like Slit2 which together contribute to defective axon guidance when altered underlying certain neurodevelopmental disorders.