Abcam, ab244433, Anti-ARHGEF5 antibody

Size: 100µL
Rabbit Polyclonal ARHGEF5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGEF5 aa 1450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGEF5 aa 1450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q12774

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGEF5 also known as Rho guanine nucleotide exchange factor 5 is a critical protein involved in the regulation of Rho GTPases. This protein acts mechanically as a catalyst exchanging GDP for GTP on Rho GTPases which are powerful regulators of the actin cytoskeleton and cell morphology. ARHGEF5 has an approximate molecular mass of 140 kDa and it is expressed in a variety of tissues including the brain heart and lungs among others. In these locations ARHGEF5 plays an essential role in enabling cellular functions that depend on cytoskeletal dynamics.
Biological function summary
ARHGEF5 actively contributes to cellular processes by modulating actin cytoskeleton organization and cell migration. It typically functions as part of signaling complexes that facilitate cellular communication and response to extracellular signals. This modulation is important for processes like cell adhesion movement and growth which are necessary for normal cellular operations and reactions to environmental changes.
Pathways
ARHGEF5 plays an integral role in the Rho signaling pathway and the focal adhesion pathway. These pathways control various cellular processes including cytoskeleton reorganization and cell adhesion both of which are essential for maintaining proper cellular structure and function. Within these pathways ARHGEF5 interacts with other key proteins such as RhoA and Rac1 amplifying its effect on cellular morphology and movement.
ARHGEF5 is associated with cancer and neurological disorders. Aberrant expression or function of ARHGEF5 has been implicated in the progress of different cancer types due to its role in cell migration and invasion. In neurological disorders ARHGEF5 may affect neuronal migration and connectivity. Additionally through its interactions with proteins like PI3K ARHGEF5 may influence cancer cell survival and proliferation further implicating its role in oncogenesis.