Abcam, ab244512, Anti-CCP1 antibody

Size: 100µL
Rabbit Polyclonal CCP1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AGTPBP1 aa 1000-1100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AGTPBP1 aa 1000-1100. The exact immunogen used to generate this antibody is proprietary information.Q9UPW5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCP1 also known as Cytosolic Carboxypeptidase 1 is an enzymatic protein important in the modulation of microtubule function. This protein is approximately 76 kDa in mass and is mainly expressed in the brain and testes but it can be found in other tissues as well. CCP1 acts by trimming the C-terminal amino acids of tubulin and other substrates impacting their stability and function. This modification plays a role in determining microtubule dynamics which are important for cell shape division and intracellular transport.
Biological function summary
CCP1 contributes to maintaining cellular functions by removing glutamates from the C-terminal of tubulin impacting microtubule behavior. It forms part of the tubulin tyrosination-detyrosination cycle and interacts with other proteins within the cycle to regulate microtubule length and stability. This regulation is essential for the proper operation of neuronal cells and can influence processes like axonal transport and signaling.
Pathways
CCP1's enzymatic activity links to microtubule and cellular cytoskeleton organization pathways. It influences the dynamic instability of microtubules essential in cell division and intracellular traffic. CCP1 interacts with other tubulin-modifying enzymes like CCP5 which together modify microtubule attributes through polyglutamylation and serve roles in cell motility and structural integrity.
CCP1 alterations or mutations have associations with neurodegenerative disorders and certain forms of cancer. Its dysfunction can lead to the progressive degeneration of neurons connected to Ataxia a condition affecting motor control. Additionally CCP1 mutations or disruptions can link to tubulin-binding proteins contributing to unregulated cell proliferation seen in some cancers. Understanding CCP1's role in these conditions can guide therapeutic strategies targeting these proteins and pathways.