Abcam, ab245634, Anti-GNL1 antibody

Size: 100µL
Rabbit Polyclonal GNL1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GNL1 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GNL1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.P36915

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab245634 was affinity purified using an epitope specific to GNL1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNL1 also known as Nucleolar GTP-binding protein 1 is a protein with a molecular weight of approximately 67 kDa. It is mainly localized in the nucleolus of the cell where it is involved in ribosome biogenesis. The protein has a role in nucleolar processes with expression noted in various tissues which suggests a universal function across different cell types.
Biological function summary
GNL1 functions as a GTPase participating in the assembly and maturation of the ribosomal subunits. This role places it as a part of the Preribosomal Complex. GNL1 facilitates ribosomal RNA processing which is essential for proper protein synthesis within the cell. The protein's involvement in these nucleolar activities supports its significance in maintaining cellular homeostasis.
Pathways
GNL1 plays an integral role in the Nucleocytoplasmic Transport and Ribosome Biogenesis pathway. It works closely alongside proteins like Nucleophosmin (NPM1) during ribosome construction. The proper interaction of GNL1 with other nucleolar proteins ensures the seamless production of functional ribosomes which are important for cellular functions such as growth and division.
GNL1 has associations with certain types of cancer due to its critical role in cell proliferation. Altered expression levels of GNL1 may contribute to tumorigenesis particularly in cancers like leukemia. The protein's interaction with Tumor Suppressor Proteins such as p53 highlights its involvement in oncogenic pathways. Dysregulation of GNL1 and its complex network of interactions should be further studied to understand its potential as a therapeutic target.