Abcam, ab245655, Anti-E2F7 antibody

Size: 100µg
Rabbit Polyclonal E2F7 antibody. Suitable for IP and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human Transcription factor E2F7 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Transcription factor E2F7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q96AV8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab245655 was affinity purified using an epitope specific to E2F7 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
E2F7 also known simply as E2F transcription factor 7 is a member of the E2F family of transcription factors. It has a unique structure compared to other E2F members lacking the DP dimerization domain. It has a molecular weight of approximately 88 kDa. E2F7 is highly expressed in various tissues including the placenta lung and kidney. This transcription factor binds to DNA and represses the transcription of target genes often acting in the G1/S transition of the cell cycle.
Biological function summary
E2F7 plays a significant role in the maintenance of cellular homeostasis. It does not rely on dimerization for DNA binding distinguishing it from other E2F proteins. E2F7 typically forms a complex with other E2F family proteins to regulate cell cycle checkpoints and control the DNA damage response. It acts as a transcriptional repressor contributing to the regulation of genes essential for DNA replication and repair.
Pathways
E2F7 is integral to the cell cycle and p53 signaling pathways. It plays a role in controlling cell proliferation by repressing genes involved in the transition from the G1 to the S phase of the cell cycle. E2F7 interacts with proteins such as p21 and p53 which are critical in cell cycle arrest and response to DNA damage. The pathway involvement highlights its part in adjusting cellular activities in response to genomic stress and maintaining genomic integrity.
E2F7 has connections to cancer and cardiovascular diseases. Dysregulated expression of E2F7 is often observed in several types of cancer linking it to tumor progression and the modulation of genes such as p53 and p21 that are vital for controlling cell division and apoptosis. In cardiovascular diseases aberrant expression patterns may affect vascular smooth muscle cell proliferation and contribute to atherosclerosis. The involvement of E2F7 highlights its potential as a therapeutic target in these conditions.