Abcam, ab245889, Anti-PTF1A antibody

Size: 1mL
Goat Polyclonal PTF1A antibody. Suitable for IHC-Fr and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Ptf1a aa 1-250.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Ptf1a aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9QX98

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTF1A also known as pancreas specific transcription factor 1a or PTFL is a bHLH (basic Helix-Loop-Helix) transcription factor with a mass of approximately 35 kDa. This protein functions as a DNA-binding protein that regulates gene expression. It is mainly expressed in the pancreas especially within pancreatic progenitor cells and also in certain neural tissues. PTF1A is necessary for the transcriptional activity of genes involved in pancreatic development.
Biological function summary
The PTF1A protein plays a significant role in pancreas development and maintenance. It forms a complex as part of the pancreas transcription factor 1 (PTF1) complex which includes other proteins like RBPJL and the E-box binding protein. This complex binds to specific regulatory regions of DNA to modulate the expression of genes important for acinar cell differentiation and function in the pancreas.
Pathways
PTF1A operates within the Notch signaling pathway and the Wnt signaling pathway. In the Notch pathway PTF1A interacts with proteins such as Notch receptors and target HES genes to influence cell differentiation. Within the Wnt pathway PTF1A impacts genes involved with cell fate decisions during pancreatic development working with signaling proteins like beta-catenin to mediate its effects.
PTF1A mutations are associated with pancreatic agenesis and cerebellar atrophy. Pancreatic agenesis involves the underdevelopment or absence of the pancreas resulting in glucose homeostasis complications. PTF1A can interact with genes such as PDX1 in this context which is another transcription factor involved in pancreatic development. In cerebellar atrophy the disruptions in PTF1A expression can lead to problems with cerebellar development causing neurological symptoms due to its interaction with neural development pathways.