Abcam, ab246013, Anti-TM2D3 antibody

Size: 100µL
Rabbit Polyclonal TM2D3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TM2D3 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TM2D3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9BRN9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TM2D3 also known as BRI3BP is a transmembrane protein with a mass of approximately 37 kDa. It is expressed in various tissues including the brain heart and skeletal muscle. TM2D3 is embedded in cellular membranes and is thought to participate in molecular signaling. It interacts with other proteins through its transmembrane domains and contributes to signal transduction pathways.
Biological function summary
TM2D3 has roles in cellular communication and regulation. It is part of a protein complex involved in modulating cellular responses to external stimuli. TM2D3 may affect processes such as cell adhesion and migration by interacting with other membrane proteins influencing cellular dynamics. Researchers continue to determine exact biological mechanisms due to its significant presence in critical tissues.
Pathways
TM2D3 integrates into the Notch signaling pathway an important pathway for cell differentiation and proliferation. Its interaction with the Notch receptor and related components influences developmental processes. Additionally TM2D3 has connections with the MAPK signaling pathway where it may modulate responses to growth factors through interactions with proteins like MEK and ERK.
TM2D3 shows relevance to Alzheimer's disease and cancer. Studies suggest that TM2D3 may interact with APP (Amyloid precursor protein) related to Alzheimer's disease affecting amyloid plaque formation. In cancer alterations in TM2D3 expression have links with tumor progression possibly involving interactions with proteins like beta-catenin that can influence cell cycle regulation and metastasis. Ongoing research aims to clarify these associations and their implications for therapeutic strategies.