Abcam, ab246859, Anti-MYOM2 antibody

Size: 100µL
Rabbit Polyclonal MYOM2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYOM2 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYOM2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.P54296

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYOM2 also known as myomesin-2 is a protein involved in muscle structure and function. It has a molecular mass of roughly 166 kDa. This protein is predominantly expressed in cardiac and skeletal muscle tissues. MYOM2 plays an important mechanical role by contributing to the M-line of the sarcomere which is essential for muscle elasticity and contractility acting as a link between myosin thick filaments and other structural proteins within the muscle cell.
Biological function summary
MYOM2 integrates into the sarcomeric M-band complex. This complex is important for maintaining the structural integrity of myofibrils. MYOM2 stabilizes interactions between the thick filament protein myosin and other M-band proteins such as myomesin-1 and myomesin-3. This stabilization supports muscle contraction processes and overall muscle fiber architecture adapting muscle cells to mechanical stress.
Pathways
MYOM2 is involved in muscle contraction and structural organization pathways. Specifically it plays a part in the myofibril assembly pathway where it collaborates with other proteins like titin and myosin binding protein C to ensure proper sarcomere assembly. These interactions help maintain the functional properties of muscle tissues contributing to force generation and transmission across muscle cells.
MYOM2 has associations with muscle-related diseases particularly hypertrophic cardiomyopathy (HCM). This disease impacts cardiac muscle and is linked with mutations or variations in MYOM2 and related proteins such as myomesin-1 and titin. Additionally MYOM2 may contribute to myofibrillar myopathy a disorder characterized by disorganization of myofibrils within muscle cells where changes in its structure can disrupt muscle function.