Abcam, ab246954, Anti-C13orf18 antibody

Size: 100µL
Rabbit Polyclonal C13orf18 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RUBCNL aa 150-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RUBCNL aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q9H714

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C13orf18 also known as Chromosome 13 Open Reading Frame 18 is a protein-coding gene with a molecular mass of approximately 30 kDa. It is expressed in various tissues most notably in the heart and throughout the central nervous system. C13orf18 acts at a molecular level by interacting with other proteins influencing cellular processes that remain not fully understood but seem significant for cellular function.
Biological function summary
C13orf18 in humans appears involved in cellular homeostasis and development. Research suggests that it might participate in a larger protein complex that facilitates intracellular signaling; however details of this complex still need clarification. The protein's expression patterns indicate a role in maintaining normal physiological functions especially within cardiac and neural tissues.
Pathways
C13orf18 engages in critical cell signaling pathways such as the Wnt signaling pathway and the cellular stress response pathway. In these pathways it may cooperate with other proteins like GSK3B in Wnt signaling modulating how signals propagate to affect gene expression. The exact pathway contribution and interactions with other proteins warrant further investigation to fully elucidate its roles.
Researchers have linked C13orf18 to specific cardiovascular diseases and neurodegenerative disorders. In cardiovascular diseases its expression pattern suggests interactions with proteins like MYH7 which may affect cardiac muscle function. In neurodegenerative contexts alterations in C13orf18 could disrupt cellular processes that lead to progression in diseases such as Alzheimer's potentially involving proteins like APP in pathological mechanisms.