Abcam, ab246957, Anti-KAT3 antibody

Size: 100µL
Rabbit Polyclonal KAT3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KYAT3 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KYAT3 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6YP21

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KAT3 also known as Cbp/p300 is a lysine acetyltransferase enzyme which plays a significant role in chromatin remodeling and transcriptional regulation by acetylating histones and non-histone proteins. Its molecular mass is approximately 265 kDa. This enzyme is expressed in a wide range of tissues indicating its participation in various cellular functions. KAT3’s widespread expression supports its involvement in multiple physiological processes critical to cell survival and differentiation.
Biological function summary
KAT3 functions as a transcriptional coactivator and is part of several transcriptional complexes. It interacts with various transcription factors enhancing their ability to regulate gene expression. By acetylating target nuclear proteins KAT3 modulates chromatin structure thereby facilitating gene transcription. This protein manipulation enables cell proliferation differentiation and maintenance of homeostasis highlighting its diverse biological roles.
Pathways
KAT3 actively participates in the signaling pathways RAS/RAF/MEK/ERK and PI3K/AKT illustrating its influence in cell growth and survival. It frequently interacts with proteins such as CREB and AP-1 which are vital in activating transcription and response to environmental signals. KAT3’s integration into these pathways highlights its critical involvement in managing cellular processes responsive to extracellular cues.
KAT3 is closely linked to cancer and Rubinstein-Taybi syndrome. Mutations or deregulation in KAT3 expression or function often result in abnormal cell growth contributing to oncogenesis. In Rubinstein-Taybi syndrome genetic mutations affecting KAT3 hinder normal developmental processes. Throughout these conditions KAT3 interacts with p53 a pivotal protein in tumor suppression and cell cycle control accentuating its relevance in maintaining cellular integrity and preventing disease progression.