Abcam, ab247055, Anti-OAT3 antibody

Size: 100µL
Rabbit Polyclonal OAT3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC22A8 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC22A8 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q8TCC7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein OAT3 also known as organic anion transporter 3 and encoded by the SLC22A8 gene plays a critical role in the transport of endogenous and exogenous organic anions. This protein has a molecular mass of approximately 60 kDa. OAT3 is primarily expressed in the basolateral membrane of kidney proximal tubule cells where it facilitates the exchange of organic anions with dicarboxylates. It contributes to the renal uptake of various substances including drugs and waste products from the blood.
Biological function summary
OAT3 serves an important role in the detoxification processes by mediating the clearance of xenobiotics and metabolites. It is not part of a larger complex but works in concert with other renal transporters to maintain homeostasis. OAT3 efficiently transports several drugs such as members of the cephalosporin family and antiviral agents and endogenous compounds like prostaglandins and cyclic nucleotides. These functions highlight its necessity in pharmacokinetics and renal drug elimination.
Pathways
OAT3 significantly impacts the renal organic anion transport pathway and the cellular response to organic substances. It participates alongside other transporters like OAT1 and OATP1B1 to manage the flow of metabolic byproducts and ensure efficient drug clearance. These interactions form an essential component of the detoxification pathway and drug disposition which are vital for maintaining organismal health.
OAT3 relates significantly to conditions such as chronic kidney disease and drug-induced nephrotoxicity. Impairments in OAT3 function can lead to altered drug excretion and accumulation of toxic substances worsening renal pathology. Additionally reduced OAT3 activity has links with urate transporter proteins like URAT1 affecting uric acid clearance and contributing to gout. Understanding OAT3 interactions and regulation helps in identifying therapeutic strategies for these conditions.