Abcam, ab247063, Anti-Sphingomyelin Synthase 1 antibody

Size: 100µL
Rabbit Polyclonal Sphingomyelin Synthase 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SGMS1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SGMS1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q86VZ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sphingomyelin Synthase 1 (SMS1) also known as sphingomyelin phosphatidylcholine transferase 1 is an enzyme that transfers a phosphatidylcholine group to ceramide forming sphingomyelin and diacylglycerol. It operates mainly in the Golgi apparatus and the plasma membrane. SMS1 has a molecular mass roughly 43 kDa. The enzyme exhibits strong expression in the liver kidney and brain indicating its importance in these tissues.
Biological function summary
SMS1 plays an important role in sphingolipid metabolism by ensuring the balance between sphingomyelin and ceramide levels. The enzyme functions within membrane and lipid-associated processes potentially affecting cellular signaling and structure. SMS1 is not part of a well-defined complex but interacts with other sphingolipid metabolism proteins which supports cellular homeostasis.
Pathways
SMS1 contributes significantly to the sphingolipid metabolic pathway and the ceramide biosynthesis pathway. These pathways are essential for maintaining cellular membranes and serve as substrates for complex lipid biosynthesis. SMS1 closely interacts with proteins like ceramide synthase and glucosylceramide synthase coordinating the flux through sphingolipid-related paths and influencing apoptotic and proliferative signals.
Disruptions in SMS1 function have links to atherosclerosis and neurodegenerative diseases. In atherosclerosis altered SMS1 activity can disrupt lipid balance encouraging lipid plaques in arteries. Furthermore SMS1 connections with proteins like acid sphingomyelinase may influence neurodegenerative conditions where sphingolipid imbalances contribute to cell death and dysfunction. These relationships highlight SMS1's emerging role in clinical research and as a possible therapeutic target.