Abcam, ab248030, Anti-TAOK2 + TAOK1 + TAOK3 (phospho S177 + S181 + S181) antibody [EPR4883] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TAOK1 phospho S181 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4883,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody recognizes Human TAOK1 when phosphorylated at Serine 181, TAOK2 when phosphorylated at Serine 181 and TAOK3 when phosphorylated at Serine 177.ab248030 cross reactivates with MEK1 due to high immunogen homology.The antibody is detecting TAOK2 + TAOK1 + TAOK3 at around 138 kDa and MAP2K1 at around 44kDa.

Product details:
ab248030 is the carrier-free version of
ab124841
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAOK2 TAOK1 and TAOK3 are members of the TAO (thousand and one amino acid) kinase family which are serine/threonine protein kinases. These kinases are known alternative names such as KINASE ORCCAN and MAP3K16. They operate through the phosphorylation of substrates to relay signals within cells a vital function in maintaining cellular processes. TAOK family proteins have varying molecular masses with TAOK2 weighing around 130 kDa. These kinases exhibit broad expression in the human body but are notably present in the brain suggesting a significant role in neurological functions.
Biological function summary
TAOK family kinases participate in the regulation of cell cycle apoptosis and stress response. They interact with various signaling complexes serving important roles in maintaining cellular homeostasis. Their ability to influence cytoskeletal dynamics further highlights their involvement in controlling cell morphology and mobility. Their activity is therefore important in ensuring that cells respond appropriately to internal and external stimuli promoting overall cellular health and function.
Pathways
The TAOK family kinases engage actively in the MAPK signaling cascade and JNK signaling pathway. Their engagement in these pathways links them to other proteins such as MAPK14 and JNK3 which play pivotal roles in transmitting stress signals thereby enabling adaptation and survival mechanisms within cells. These signaling routes allow cells to adjust to changes in the environment by regulating gene expression and cellular responses.
Altered TAOK kinase activity connects to neurodevelopmental disorders such as autism spectrum disorder and neurodegenerative conditions like Alzheimer's disease. Disruptions in TAOK signaling may affect proteins such as NRXN1 and APP known for their roles in synaptic function and neuronal integrity respectively. These connections emphasize the importance of TAOK kinases in neural tissue and highlight potential avenues for therapeutic interventions targeting these kinases in relevant neurological diseases.