Abcam, ab248357, Anti-RGS22 antibody [EPR7005] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RGS22 antibody. Carrier free. Suitable for WB and reacts with Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7005,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248357 is the carrier-free version of
ab131048
This antibody was developed as part of a collaboration with the lab of Damian Romero at the University of Mississippi Medical Center.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGS22 also known as Regulator of G-Protein Signaling 22 is a member of the RGS protein family with a molecular weight of approximately 155 kDa. This protein modulates the activity of G-proteins by accelerating the deactivation of GTP-bound alpha subunits. RGS22 reduces the lifespan of active G-protein signaling playing a role in signal termination. Expression occurs largely in the testes and it's found in smaller amounts in other tissues like the brain.
Biological function summary
This protein impacts reproductive and neuronal signaling. It forms part of signal transduction complexes that regulate physiological processes. RGS22 interacts with other proteins and cellular components to maintain the proper function of G-protein signaling in specialized tissues. Its activity influences key cellular responses essential for the regulation of several processes particularly in tissues where signaling accuracy requires precise control.
Pathways
RGS22 participates prominently in the G-protein-coupled receptor (GPCR) signaling pathway and the Wnt signaling pathway. Within these pathways RGS22 associates with the G-protein alpha subunits to modulate signal transduction and cellular responses. It interacts with proteins like Gαs and Gαi which are part of the broader network of signaling proteins. These pathways highlight the regulatory role of RGS22 in complex cellular functions and physiological responses.
Abnormal expression or function of RGS22 associates with reproductive disorders and certain neurological diseases. Its dysregulation might contribute to issues like infertility through its impact on signaling in the testes. In neurological contexts RGS22 has been connected to disorders where G-protein signaling balance is disrupted potentially associating with proteins like Gα subunits. Understanding RGS22's role in these diseases could aid in developing targeted therapies.