Abcam, ab248617, Anti-Elp4 antibody [EPR4200(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ELP4 antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4200(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248617 is the carrier-free version of
ab133687
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Elp4 also known as Elongator complex protein 4 has an important role in the transcription process within cells. Its molecular weight is approximately 46 kDa. Elp4 is expressed in multiple tissues throughout the body with higher presence observed in the brain. It works as a component of the larger Elongator complex collaborating with other proteins such as Elp1 Elp2 Elp3 Elp5 and Elp6.
Biological function summary
Elongator complex proteins contribute to various cellular functions. Elp4 plays an important role in facilitating the modification of tRNA molecules necessary for efficient protein translation. It acts as part of the Elongator complex which participates in transcriptional elongation impacting processes like acetylation of histone 3 lysine 14. Elp4's activity in these processes ensures the proper progression and regulation of gene expression.
Pathways
Elp4 integrates into several significant cellular pathways. Notably it is active in the transcriptional elongation pathway an important process for proper gene expression. It also interacts with the oxidative stress response pathway aiding cells to manage stress. Within these pathways Elp4 collaborates closely with other elements of the Elongator complex ensuring synchronized functioning in transcription and stress response.
Research indicates that mutations or dysfunctions in Elp4 can contribute to several neurological conditions particularly juvenile-onset dystonia. This connection links Elp4 indirectly with other proteins involved in neural function such as dopamine receptor pathways. Additionally Elp4 is implicated in neurodevelopmental disorders like Rolandic epilepsy where its interaction with other components in the neuronal signaling may be disrupted.