Abcam, ab248780, Anti-Lhx8 antibody [EPR5213(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal LHX8 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5213(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248780 is the carrier-free version of
ab137036
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Lhx8 known also as LIM homeobox 8 functions as a transcription factor with a molecular weight of approximately 31 kDa. This protein is part of the LIM homeobox family characterized by the presence of LIM and homeodomain motifs. Lhx8 is mainly expressed in the nervous system and reproductive organs. Expression of Lhx8 has been observed in neuronal tissue specifically influencing neural differentiation and development as well as in the gonads where it plays a role in reproductive system development.
Biological function summary
Lhx8 regulates the expression of genes involved in the differentiation of specific cell types. It plays an important role in early development and differentiation processes. Lhx8 participates in cell fate decisions directing stem cells towards specific lineages. It does not operate alone but forms complexes with other proteins including Lhx members to exert its effects on cell differentiation particularly in the nervous system and reproductive tissues.
Pathways
Lhx8 integrates into several important developmental pathways. It is notably active within the retinoic acid signaling pathway which guides cellular differentiation and development. Lhx8 also interacts with Wnt signaling a pathway essential for cell proliferation and fate determination. In these pathways Lhx8 might relate to proteins like β-catenin and other LIM proteins demonstrating its integrative role in facilitating precise developmental processes.
Lhx8 shows relevance in conditions such as infertility and neurodegenerative diseases. Abnormal Lhx8 expression or function has been linked to fertility issues highlighting its involvement in gonadal development. Lhx8's interaction with known neurodegenerative disease-related proteins like those of the retinoic acid pathway indicates its potential connection to neurodegenerative conditions. By understanding Lhx8's role researchers can decipher its contributions to these disorders aiding in potential therapeutic development.