Abcam, ab248845, Anti-WDR68 antibody [EPR8712] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal WDR68 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8712,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248845 is the carrier-free version of
ab138490
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR68 also known as DCAF7 or Han11 is a protein with a mass of approximately 40 kDa. It functions mechanically as a scaffold protein facilitating interactions between various signaling molecules. WDR68 is expressed broadly across different tissue types including the brain heart and skeletal muscle. Its role as a scaffold indicates its importance in organizing and stabilizing multi-protein complexes that regulate numerous cellular processes.
Biological function summary
The WDR68 protein interacts with other cellular components to regulate signaling pathways important for cell proliferation and differentiation. It forms a part of the STRIPAK complex which plays a role in modulating developmental processes and cellular stress responses. The protein contributes to the maintenance of cellular structure and function influencing activities like gene expression and signal transduction.
Pathways
WDR68 operates within the MAPK and JNK signaling pathways both of which are essential for transmitting external stimuli to intracellular responses. Within the MAPK pathway WDR68 interacts with kinases such as MAP3Ks facilitating the transduction of mitogenic signals. The JNK pathway involves proteins like MKK4 with WDR68 playing a role in modulating various cellular responses including those involved in apoptosis and stress responses.
WDR68 associates with craniofacial development abnormalities as its interaction with the DYRK1A protein influences cellular signaling during neural crest cell development. Mutations or dysregulations in WDR68 are also linked to cancer progression due to its role in the MAPK pathway affecting cell cycle regulation and apoptosis. The relationship between WDR68 and cancer highlights the involvement of proteins such as MKK4 making it significant in therapeutic research targeting these pathways.