Abcam, ab248892, Anti-DHRS7 antibody [EPR9338(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal DHRS7 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9338(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248892 is the carrier-free version of
ab140596
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHRS7 short for dehydrogenase/reductase 7 is an enzyme involved in oxidation-reduction reactions. This protein has a molecular mass of approximately 37 kDa. As part of the short-chain dehydrogenase/reductase family which is notable for its role in metabolizing a wide range of substrates DHRS7 is expressed in several tissues including liver kidney and brain. It contributes to the conversion of various small molecules although the specific substrates it acts on remain less completely defined.
Biological function summary
DHRS7 influences cellular processes by participating in steroid and retinoid metabolism. It operates as an independent enzyme rather than as part of a larger complex. Its activity affects the balance of oxidized and reduced states of substrates impacting cell signaling and homeostasis. The enzyme modifies key signaling molecules potentially influencing the receptor activities that these molecules regulate therefore playing a role in cellular responses and adaptation.
Pathways
DHRS7 integrates into metabolic and signaling pathways through its function in oxidation-reduction reactions. It participates in the steroid metabolism pathway where it perhaps interacts with cytochrome P450 enzymes that mediate a variety of biosynthetic processes. DHRS7 may also engage in the retinoid metabolic pathway related through the mutual need for enzymes capable of handling lipid-soluble vitamins and hormones. Its interaction with other enzymes in these pathways helps maintain cellular equilibrium and contributes to broader metabolic networks.
DHRS7 interactions have been linked with metabolic syndrome and liver disease. Abnormal activities of DHRS7 have been observed in conditions involving disrupted metabolic states suggesting a link to liver disease through impaired processing of substrates in the liver. The altered function of this enzyme can also affect pathways involving other proteins like cytochrome P450 leading to ripple effects in metabolic disorders such as atypical steroid processing in metabolic syndrome indicating the importance of DHRS7 in maintaining normal cellular physiology.