Abcam, ab248918, Anti-Cytochrome P450 4A/CYP4A11 antibody [EPR8276] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Cytochrome P450 4A/CYP4A11 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8276,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen is homologous to human cytochrome P450 4A11 and 4A22. The specificity to these specific forms has not been confirmed experimentally.

Product details:
ab248918 is the carrier-free version of
ab140635
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytochrome P450 4A also known as CYP4A11 plays an important role in the metabolism of fatty acids and arachidonic acid. This enzyme is a member of the cytochrome P450 superfamily and possesses a molecular mass of approximately 58 kDa. Expression of CYP4A11 occurs mainly in the liver and kidneys. It functions by introducing oxygen into various substrates facilitating their breakdown and further processing. CYP4A11 also exists as a monomer and does not require assembly into larger complexes to function efficiently.
Biological function summary
Cytochrome P450 enzymes like CYP4A11 contribute significantly to the metabolism of long-chain fatty acids. These metabolic processes generate substances important for cell signaling such as hydroxyeicosatetraenoic acids (HETEs). The enzyme also participates indirectly in blood pressure regulation through these metabolic products. Although CYP4A11 does not form part of a protein complex the metabolic byproducts have a role in several cellular mechanisms.
Pathways
CYP4A11 is integral to the fatty acid signaling pathway. Its action leads to the production of 20-HETE a metabolite involved in regulating vascular tone and renal function. Related proteins in this pathway include other cytochrome P450 family members particularly those involved in arachidonic acid metabolism like CYP2E1. Although not directly a part CYP4A11's metabolic activities feed into the pathways that control blood flow and pressure closely linking it to cardiovascular mechanisms.
CYP4A11's activity connects to hypertension and atherosclerosis. Dysregulation of its metabolic processes can lead to imbalances in fatty acid derivatives contributing to these conditions. Studies indicated a link between CYP4A11 and cardiovascular diseases with alterations in enzyme activity affecting blood pressure. The protein links to other P450 enzymes that similarly metabolize fatty acids and participate in maintaining cardiovascular health. Notably CYP4A11's influence on hypertension makes it a target for research into antihypertensive therapies.