Abcam, ab249010, Anti-Chromogranin B antibody [EPR9567] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Chromogranin B antibody. Carrier free. Suitable for WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9567,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249010 is the carrier-free version of
ab151568
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Chromogranin B also known as secretogranin I is a member of the granin protein family and is sometimes referred to alongside chromogranin A and other chromogranins. Chromogranin B is a secretory protein with a known mass of approximately 80 kDa. This protein expresses primarily in neuroendocrine cells where it localizes to the secretory granules. Chromogranins including chromogranin B play a role in the formation and stabilization of secretory granules important for storing and releasing peptide hormones and neuropeptides.
Biological function summary
Chromogranin B functions beyond merely being a constituent of secretory granules. It plays a role in the regulation of neuroendocrine secretion processes and interacts with the chromogranin core complex. This complex is involved in the packaging and sorting of peptides and hormones within cells. Chromogranin B also exhibits roles in modulating calcium-binding dynamics which is critical for cellular signaling and hormone secretion. Unlike chromogranin A chromogranin B is less abundant but still significant for cellular processes.
Pathways
Chromogranin B prominently aligns with the secretory pathway associated with neuroendocrine tissues. This pathway involves several proteins like chromogranin A that often work alongside chromogranin B to influence hormone release. Another pathway where chromogranin B plays a role involves the regulation of catecholamine release vital for stress responses. This particular involvement with catecholamines links chromogranin B to its role in neurotransmitter regulation.
Chromogranin B shows an association with conditions such as neuroendocrine tumors and hypertension. In neuroendocrine tumors chromogranin B can serve as a biomarker since its levels often elevate in these conditions akin to chromogranin A. Hypertension studies suggest connections between chromogranin B and the dysregulation of catecholamine release impacting blood pressure regulation. Understanding the role of chromogranin B and its related proteins can help in diagnosing and potentially targeting these disorders.