Abcam, ab249135, Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MSY2/YBOX2/YBX2 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2814(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249135 is the carrier-free version of
ab154829
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MSY2 also known as YBOX2 or YBX2 is a protein involved in gene regulation specifically affecting mRNA stability and translation. The protein has a molecular mass of approximately 36 kDa. MSY2 is a germ cell-specific protein primarily expressed in testes and ovaries. It plays an important role during gametogenesis and early embryogenesis by binding with mRNA and forming messenger ribonucleoprotein (mRNP) complexes and therefore controlling mRNA metabolism.
Biological function summary
MSY2 functions as a regulator of mRNA translation and storage. It is part of a ribonucleoprotein complex that safeguards mRNAs during gametogenesis. This protein displays specificity in binding to Y-box motifs on mRNA which allows it to regulate gene expression and protein synthesis at a posttranscriptional level. Its function ensures correct development of germ cells contributing to reproductive success.
Pathways
MSY2 integrates into posttranscriptional regulatory mechanisms and is important for mRNA stability within these pathways. One such pathway involves cytoplasmic deadenylation and translational control during oocyte maturation. MSY2’s role also extends to working closely with other proteins such as YBX1 which shares similar functions in mRNA regulation further highlighting the interconnected nature of its activity.
MSY2’s deregulation can lead to fertility issues particularly affecting spermatogenesis. Aberrant expression of MSY2 affects mRNA stability and may result in testicular dysfunction. It also connects with proteins like DAZL which is another germ cell-specific regulator suggesting that perturbations in this network can affect germ cell viability and lead to reproductive disorders. Proper expression and regulation of MSY2 are therefore essential for maintaining reproductive health.