Abcam, ab249501, Anti-KBTBD11 antibody [EPR10056(2)(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal KBTBD11 antibody. Carrier free. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10056(2)(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249501 is the carrier-free version of
ab169551
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KBTBD11 also known as Kelch Repeat and BTB (POZ) Domain-Containing Protein 11 is a protein with a molecular mass of approximately 70 kDa. This protein is part of the BTB-Kelch family which are characterized by a BTB protein-protein interaction domain and Kelch repeats that form a beta-propeller structure. KBTBD11 is expressed in various tissues with higher expression seen in the brain and testis indicating a role in neural activities and reproductive processes.
Biological function summary
KBTBD11 participates in the ubiquitin-proteasome system where it acts as a substrate adaptor for Cullin-RING E3 ligases (CRLs). By facilitating the ubiquitination of target proteins KBTBD11 regulates protein turnover and stability. It does not function independently and is part of a larger CRL complex that includes various other scaffolding and substrate recognition proteins. Through these interactions KBTBD11 impacts cellular processes such as signal transduction and cell cycle progression.
Pathways
KBTBD11 is involved in the ubiquitination and proteasome degradation pathways critical for maintaining proteostasis within cells. It shares functional relationships with other components like Cullin-3 which form an E3 ligase complex important for tagging damaged or unneeded proteins for degradation. This regulatory mechanism plays a significant role in controlling signal transduction pathways including cell growth and apoptotic processes in which protein degradation must be swiftly and accurately regulated.
KBTBD11 links to neurodegenerative diseases and cancers due to its role in protein degradation. Misregulation of its function can lead to an accumulation of ubiquitinated proteins which is a hallmark of neurodegenerative conditions such as Alzheimer’s disease. It may also be involved in cancer through pathways associated with cell cycle control where its malfunction can contribute to uncontrolled cell proliferation. In these contexts proteins like p53 are often critical in mediating the pathways impacted by KBTBD11 dysfunction.